| dc.description.abstract | Objective: to know the comparison of malondialdehyde (MDA) levels in
severe preeclampsia and normotensive pregnancy, where MDA rs one
sign of endothelial damage.
Methods: This study was cross-sectional study. Analysis of the study
vaiables with bivariate analysis method is Chi-square; coffetation between
MDA with increased blood pressure patients arc numeicaldata expressed
in the Spearman conelation coefficient (r). The research was conducted
on matdmity and outpatient units of pregnant women Adam Malik Hospital
and Sentinel Hospitals. Ihe study was stafted in May 2012 until minimum
sample s2e rs met. The sample was 56 people that all pregnant women
are examined pregnancy in obstetics c/rnrbs and hospital emergency
rooms of Adam Malik Hospital and Sentinel Hospitals. lnclusion citeia
include single fetus, multigravida or primigravida with ges:tational age >20
weeks, severe preeclampsia, normotensive pregnancies as controls,
exclusion citeria was damaged or faulty blaod during blood sampling
procedure
Resulfs; The mean (SD) gesfational age notmotensive group was 35.8
(3.36) weeks, while the mean (SD,) gesfational age preeclampsia group
was 34.6 (3.5) weeks (p = 0.193). lncidence of preeclampsia in
pimigravida were 11 (19.6%) and the normotensive pregnant women 12
(21.4o/o) peoples. lncidence of preeclampsia in multigravida were 16
e8.6n and the normotensive pregnant women were 13 (X.zn peoples.
lncidence of preeclampsia in grandemultigravida 1 (1.8) and the
normotensive pregnant women 3 (5.4yo) peoples (p = 0.508). The resu/fs
a/so showed the incidence of preeclampsia in nullipam were 11 (19.6%0)
and the normotensive pregnant women wete 13 (23.2W peoples.
lncidence of preeclampsia in multiparas were 17 (30/W peoples and in
normotensive pregnant women 15 (26.8W peoples. lncidence of
preeclampsia in grandemultipara not found as well as normotensive
pregnant women. (P - 0.589). lncidence of aboftion in normotensive
pregnant women is higher than in preeclampsra 6 (10.7%0) while those if
pregnant women with preeclampsia 3 (5.4%o) peoples (p = 0.275).
Educational background on the mosf severe preeclampsia are senior high school grcduates a total of 12 (21.4%o) people, followed by primary school
7 (12.5W people, scholars 3 (5.4n and the junior high school 6 (10 , 7%o)
peoples. While at the high school educational background normotensive
by 15 (26.8W people, junior high schoolT (12.5%) people, primary school
3 (5.4%o) people, and scho/ars 3 (5.4% ) people (p = 0.510). The mean
systolic blood pressurc in patients with preeclampsia is 181.78 mm Hg
(SD = 9.4) with a diastolic blood pressure of 98.57 mm Hg (SD = 5.9) (p
<0.001). Mean MDA levels in patients with severe preeclampsia was 3.88
nmol / ml(SD = 0.1) whereas fhe normotensive pregnant women was 1.04
nmol / ml(SD = 0.05), p <0.001. Spearman corelation fesf rcsu/fs showed
a very strong conelation between the degrce of sysfolic and diastolic
pressure with MDA levels (conelation coefficient = 0.879 systolic and
diastolic = 0.885) in which the diastolic blood pressure is more strcngly
conelated than the systolic blood pressure.
Conclusions: The mean levels of MDA in patients with severe
preeclampsra was 3.88 nmol / ml (SD = 0.1) whereas fhe normotensive
pregnant women was 1.04 nmol / ml (SD - 0.05), indicating that MDA
levels more significantly higher than average levels of MDA in
normotensive pregnant women with a p value <0.001 | en_US |
