Korelasi Lymphovascular Invation dengan Carcinoembryonic Antigen sebagai Indikator Prognostik pada Pasien Pasca Operasi Kanker Kolorektal di RSUP. H. Adam Malik Medan

Abstract

Background: Several prognostic factors have been proposed to reflect the course of the disease, such as demographic, histopathological, immunological, molecular, and multidisciplinary interventions. Histological examination is widely used to predict prognosis and optimize adjuvant treatment, such as LVI and CEA. Methods: This study is a literature review that aims to see the correlation between LVI and CEA as a postoperative prognostic indicator. This is a development from previous studies regarding CEA levels on chemotherapy response. Results: CEA normalized in more than 70% of patients after surgery, and the outcomes of patients with postoperative CEA who returned to normal were similar to those with normal preoperative CEA. Lymphovascular invasion is an independent poor prognostic marker for survival in colorectal cancer. Node-negative patients, particularly stage II, are the most important group that could benefit from the identification of LVI. Conclusion: Serum CEA and LVI levels have the potential to be better biomarkers for the prognosis of colorectal cancer patients