| dc.description.abstract | Background: SARS-CoV-2 infection in pregnant women is a new infection, and
little is known whether infection with this virus can spread transplacental and the
possible effects on children and their outcomes in infants born to mothers with
SARS-CoV-2 infection are still unknown for certain, so we are interested in
analyzing how the outcomes of infants from mothers infected with SARS-CoV-2
and whether there is a possibility of vertical transmission from mother to baby
Objective: to see the characteristics of SARS-CoV-2 infection in the placenta and
the possible outcomes that occur in newborns from mothers infected with SARSCoV-
2 (confirmed by RT-PCR)
Methods: This hospital-based cross-sectional study was done on 28 mother-infant
couples from February 2021 to December 2021 utilizing a systematic sampling
strategy. Kami mengambil plasenta dan melakukan pemeriksaan histopatologi dan
pewarnaa IHC to see the expression of the SARS-CoV-2 N protein in the placenta
using the SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] (GeneTex)
antigen. The SPSS program was used to examine the data (version 26). To find
related variables with 95% confidence intervals, chi-square analysis, Fisher exact
test, Mann-Whitney, and Independent T test were calculated.
Result: We conducted a study on 28 pregnant women who were confirmed to be
infected with SARS-CoV-2 based on RT-PCR examination. We found the N
protein expression of SARS-CoV-2 in two placentas, but none of the infants was
confirmed to be infected with SARS-CoV-2. In our analysis, we did not find an
increase in morbidity and mortality of infants born to mothers infected with SARSCoV-
2, but we did find an increase in maternal morbidity and mortality.
Conclusion: SARS-Cov-2 can infect the placenta, so that vertical transmission
from mo ther to baby is still possible | en_US |
