| dc.description.abstract | Background: Thalassemia is a genetic hematologic disorder that needs a
lifetime transfusion. It will cause heart disease, endocrinopathies including
abnormalities of bone profile. Study in Mosul show that association between
duration of iron chelation agent and biochemical bone profiles (alkaline
phosphatase)
Objective: To determine the effect of longterm use of iron chelating agent to
biochemical bone profile in thalassemia patients.
Methods: A cross sectional study was conducted in Haji Adam Malik hospital
and Sari Mutiara hospital Medan, on July until September 2015. Biochemical
bone profile measurement were performed to all subjects. Data was analyzed
using Spearman correlation test and P value less than 0.05.
Results: 33 thalassemia children were enrolled this study. Mean age of the
subject was 1 O years old (SD: 3.90), and the mean time of using iron
chelation was 6 month (SD: 3.42). Bone profile measurement showed that
mean level of calcium was 9 mg/DI (SD: 0.86), phosphor was 4.6 mg/DI (SD:
0.66), alkaline phosphatase was 293.2 IU/L (SD:157.40), and serum albumin
was 3.8 g/DI (SD:0.50) . Spearman correlation test showed no significant
correlation between duration of iron chelation agent and biochemical bone
profiles (P: >0.05). Correlation for each association between duration of iron
chelation agent used and bone profile were as follows calcium (r=0.196),
phosphor (r = -0.219), alkaline phosphatase (r = 0.251), and albumin (r =
0. 155) there was weak correlation.
Conclusion: Longterm used of iron chelating agent has weak correlation
with biochemical bone profile in thalassemia patients | en_US |
