Pengaruh Krim Ekstrak Kulit Jeruk Manis (Citrus Sinensis L.) 0,1% terhadap Hiperpigmentasi Pascainflamasi di Aksila

Abstract

Background: Postinflammatory hyperpigmentation is not a harmful condition, but can affects appearance and quality of life. Postinflammatory hyperpigmentation occurs due to increase melanin production after cutaneous inflammation. Sweet orange (Citrus sinensis L.) is widely cultivated in North Sumatra. The peels, which are industrial waste, contain bioactive components such as flavonoid which play a role in improving pigmentation through antioxidant and tyrosinase inhibition mechanisms. Objetive: To determine the effect of 0.1% sweet orange peel extract cream (Citrus sinensis L.) on axillary hyperpigmentation. Methods: This pre-experimental clinical trial study was conducted with a pretestposttest design on 32 subjects with axillary hyperpigmentation. Diagnosis was made through history taking and clinical evaluation. Melanin index was evaluated using Mexameter® MX 18 before and after the administration of 0.1% sweet orange peel extract cream, carried out at weeks 0, 2, 4, 6, and 8. Clinical evaluation was made using Physician Global Assessment. Side effects were recorded during study, and level of satisfaction was assessed at the end of study. Friedman test was carried out to see the difference before and after treatment with a p-value <0.05, is considered significant. Results: There was significant decrease in melanin index on axillary hyperpigmentation (p<0.001) after eight weeks administration of 0,1% sweet orange peel extract cream. Clinical improvement and no side effects were also noted. All subjects were satisfied by the application of 0.1% sweet orange peel extract cream. Conclusion: The use of 0.1% sweet orange peel extract cream can improve pigmentation and decrease melanin index in axillary hyperpigmentation with no side effects and good satisfaction.