Efektivitas Vitamin B6 terhadap Kuantitas Osteoblas dan Osteoklas pada Pergerakan Gigi pada Tikus Wistar

Abstract

Effectiveness of Vitamin B6 on the Quantity of Osteoblast and Osteoclast in Tooth Movement in Wistar Rats xii + 63 pages Orthodontic tooth movement depends on remodeling of periodontal ligament and alveolar bone. Cells found in alveolar bone in response to orthodontic tooth movement are osteoblasts and osteoclasts. This study aims to determine vitamin B6 effectiveness on tooth movement, osteoblast and osteoclast cells count to provide information about vitamin B6. This research is an experimental research with pretest-posttest control group design. This study used 24 Wistar rats which were divided into 3 groups with 1, 3 and 7 days observation time. Coil spring was applied in Wistar rats maxilla and observed based on subgroups. The tooth movement was measured using the CorelDraw application with split mouth method and the cell count of osteoblasts and osteoclasts were done histologically. Tooth movement increased since day 1. The results of the Kruskal Wallis test showed that there was a significant difference in the treatment group (p<0.05) and no significant difference between observation time (p>0.05). ANOVA test showed that there was a significant difference in the number of osteoblasts of the two groups on both sides which were observed and the number of osteoclasts was only present in the treatment group on both sides and the treatment group on the control side (p<0.05). The conclusion of this study is vitamin B6 supplementation inhibits tooth movement, the number of osteoblasts and osteoclasts. References: 62 (2007-2022)