| dc.description.abstract | Background: Infectious diseases are a major problem especially in poor and
developing countries including Indonesia. The most common cause is bacterial
infections such as Klebsiella pneumonia and Staphylococcus aureus. Based on
previous research, it is known that sungkai leaves contain secondary metabolite
compounds such as alkaloids, steroids, phenolics, tannins, and saponins that have
potential as antibacterials.
Objective: This study aims to determine the content of chemical compounds
contained in the simplicity and ethanol extract of sungkai leaves and test the
antibacterial activity of ethanol extract of sungkai leaves against Klebsiella
pneumonia and Staphylococcus aureus.
Methods: This study was conducted with experimental methods including
characterization of sungkai leaves simplicity, phytochemical screening test,
extraction by reflux method using ethanol p.a and testing antibacterial activity
using disc diffusion method with various concentrations.
Results: The results of simplicity characterization obtained a moisture content of
9.99%, water soluble juice content of 10.28%, ethanol soluble juice content of
14.5%, total ash content of 3.829%, and acid insoluble ash content of 0.421%.
Chemical compounds contained in simplicity and ethanol extracts of sungkai
leaves are alkaloids, saponins, flavonoids, steroids, glycosides, and tannins.
Ethanol extract of sungkai leaves has antibacterial activity against Klebsiella
pneumonia and Staphylococcus aureus with Minimum Inhibitory Concentration
against Klebsiella pneumonia at a concentration of 1.5625 mg/mL with an
inhibition zone diameter of 6.4 mm and on Staphylococcus aureus bacteria at a
concentration of 1.5625 mg/mL with an inhibition zone diameter of 6.97 mm.
Conclusion: Ethanol extract of sungkai leaves (Peronema canescens Jack.) has
antibacterial activity against Klebsiella pneumonia and Staphylococcus aureus. | en_US |
