| dc.description.abstract | Candida albicans is a normal flora can become a pathogen called opportunistic
infection. Tamarind seed coat (Tamarind indica L.) has antifungal substances in the
form of polyphenols, taninns, anthocyanin, dan oligomeric proanthocyanidin. The
predisposing factors such as the use of dentures that are not removed and cleaned can
cause denture stomatitis. The purpose of this study was to determine the zone of
inhibition, Minimum Inhibitory Concentration (MIC), and Minimum Fungicidal
Concentration (MFC) of tamarind seed coat extract concentration 3,125%, 6,12%,
12,5%, 25%, dan 50%, Chlorhexidine gluconate 0,2% as positive control, and DMSO
as a negative control against Candida albicans ATCC®
10231TM. The experimental
laboratory research method with a post test only control group design. The inhibition
zone by the blank disk diffusion method was measured using digital caliper Kirby Bauer, while the MIC and MFC tests used the dilution method with Standard Mc
Farland. Tamarind seed coat were extracted by maceration technique from each
concentration added to the fungal suspension, repetition was carried out 4 times and
then observations were made. Data analysis used the Kruskall wallis test followed by
the Mann-Whitney. The results of the study obtained the value zone of inhibition of
concentrations of 3.125%, 6.25%, 12.5%, 25%, and 50% on average 10,19 mm, 12,13
mm, 15,50 mm, 18,56 mm, dan 24,56 mm, and Minimum Inhibitory Concentration
(MIC) 12,5%, Minimum Fungicidal Concentration (MFC) 25%. The conclusion is that
there was the zone of inhibition, Minimum Fungicidal Concentration (MFC), and
Minimum Inhibitory Concentration (MIC) the effect of tamarind seed coat extract on
the growth of Candida albicans ATCC®
10231TM with a significance value (p=0,001). | en_US |
