Sintesis 2-N-(Pentanadioat)-(12-Dodekanoiloksi) Oktadeka-9-Enamida Melalui Reaksi Esterifikasi Metil Risinoleat dengan Asam Laurat yang Diikuti Amidasi dengan Asam Glutamat

Abstract

Methanolysis of castor oil produce of fatty acid methyl ester castor oil. Methyl ricinoleic as main composition in castrol oil could be acetylated with acetic acid anhydride give 12-acetoxy 9-octadecenoate, which then purified with column chromatography using eluent mixture of petroleum ether and diethyl ether (19: 1 v/v), yield percent is 71,0% Interesterification 12-acetoxy 9-octadecenoate with methyl laurate at 65°C using catalyst NaOCH3 in dry methanol at reflux condition for 6-8 hours yield 68.7% of 12-dodecanoiloxy 9-octadecenoate. Amidation 12-dodecanoiloxy 9-octadecenoate with glutamic acid at 80°C in vacum condition yield 54.3% of 2-N-(pentanadioate)-(12-(dodecanoiloxy) octadeca-9-enamide], with melting point 104- 108°C and HLB was 3.45. Each reaction product was confirmed with FT-IR and 1H-NMR spectroscopy.