| dc.description.abstract | CuNiTi orthodontic wire is one type of wire used in orthodontic treatment that has the potential to release nickel ions. One factor is fluoride ions contained in various oral hygiene products such as mouthwash. The purpose of this study was to see the difference in the amount of nickel ion release in CuNiTi wire immersed in pure artificial saliva and artificial saliva added with 0.05% sodium fluoride (NaF) for 2, 4, and 6 weeks. This research is a laboratory experimental study using a post-test only control design. The sample used is CuNiTi orthodontic wire with a length of 4 cm. The samples were divided into 2 groups, the control and the treatment group and each group consisted of 10 samples. The samples were immersed in the control and the treatment solution and then kept in a 37̊C incubator for 2, 4, and 6 weeks. The sample was removed from the solution and the solution was tested using an atomic absorption spectroscopy (AAS). The results showed the mean release of nickel ions in the control and treatment groups increased with increasing immersion time. Based on the results of the analysis of the Mann-Whitney test showed a significant difference between the control group and the treatment group at weeks 2nd and 6th with a p-value ≤0.05, while at week 4 there was no significant difference with a p-value ≥0.05 (0.201). So it can be concluded that there is a significant different release of nickel ions in CuNiTi wire immersed in artificial salivary solution with 0.05% sodium fluoride (NaF) added at 2 week and 6 week, while at 6 week there was no significant difference | en_US |