Hubungan antara Kadar Imunoglobulin M, Imunoglobulin G, dan Hitung Cluster Differentiation 4 dengan Fungsi Kognitif Pasien Toksoplasmosis Serebri dengan Human Immunodeficiencyvirus Positif di Rumah Sakit Umum Pusat Haji Adam Malik

Abstract

Background: Cerebral Toxoplasmosis is an intracranial infection that is caused by Toxoplasma gondii. In healthy population, infection of Toxoplasma is asymptomatic, but in immunosuppressed condition like HIV (Human ImmunodeficiencyVirus) infection there is risk of reactivation latent Toxoplasma. Both HIV and Toxoplasma infection can impair the cognitive function. Purpose: To find the relationship between Cluster Differentiation 4 (CD4,cells/mm3) , Immunoglobulin M (IgM, IU/mL) antitoxoplasma, Immunoglobulin G (IgG, IU/mL) antitoxoplasma and cognitive function in patient with Toxoplasma cerebri HIV positive Methods: This is a cross sectional study. Subject in this study is all the patient with confirmed Toxoplasma Cerebri and positive HIV infection who met the inclusion and exclusion criteria. Total subject is 110 patient. To determine the relationship between the IgM and Ig G antitoxoplasmosis and cognitive function, the spearman test was used. To determine the relationship between CD4 and cognitive function, the Fisher’s Exact test was used. Results: There is no significant relation between IgM antitoxoplasma and cognitive function (p=0.285 r = - 0.103). But there is a significant of IgG antitoxoplasma with cognitive function (p=0.004, r = - 0.275). And there is a significant relationship between CD4 and cognitive function (p = 0.003) Conclusion: There is a significant relation between IgG antitoxoplasma and cognitive function. There is a significant relationship between CD4 and cognitive function In this study the relationship between IgM antitoxoplasmosis and cognitive function is not significant.