Formulasi dan Uji Aktivitas Imunomodulator Nanoliposom Ekstrak Etanol Terung Bulat Hijau (Solanum xanthocarpum Schrader & Wendland) pada Tikus Jantan

Abstract

Immunomodulators are substances that can modulate the function and activity of the immune system by stimulating or improving the function of the immune system. Immunomodulators that are currently being developed are those from nature, one of which is the green round eggplant (Solanum xanthocarpum Schrader & Wendland). The purpose of this study was to determine the immunomodulatory activity and the most effective concentration of liposomes in green eggplant extract in male rats. This research includes the collection and processing of plant materials, manufacture of simplicia, characterization of simplicia, manufacture of extracts, manufacture of liposomes with thin layer hydration method, and testing on white rats with the carbon clearance method. Immunomodulatory testing using the carbon clearance method was given to the control group (positive: imboost syrup, negative: Na CMC), and extract and nanoliposomes the test group (dose of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW). The results showed that the carbon elimination constant for the negative 0.0028; positive 0.0135; green round eggplant ethanol extract nanoliposomes dose 25 mg/kg BW 0.0061; dose 50 mg/kg BW 0.0091; dose of 100 mg/kg BW 0.0119; green round eggplant dose 25 mg/kg BW 0,0036; dose 50 mg/kg BW 0,0056; dose 100 mg/kg BW 0,0102. The results of the phagocytosis index in the negative group were negative 2.5820; positive 5.8524; green round eggplant ethanol extract nanoliposomes dose of 25 mg/kg body weight 4,3131; dose 50 mg/kg BW 5.0635; dose of 100 mg/kg BW 5.5205; Green round eggplant ethanol extract dose 25 mg/kg BW 3,6300; dose 50 mg/kg BW 4,1800; dose 100 mg/kg BW 5,1089. This shows that the green round eggplant extract nanoliposome fulfills the characterization and has an immunomodulatory effect.