Hubungan Rasio Triglyceride/High Density Lipoprotein Cholesterol dengan Severitas Lesi Koroner pada Pasien Infark Miokard Akut di RSUP Haji Adam Malik Medan

Abstract

Background: Coronary heart disease is the leading cause of worldwide death. A number of markers have been identified in terms of the atherogenic potential of the lipid profile.The TG/HDL-C ratio is an easy and economical non-invasive examination method as a predictor of coronary heart disease severity. The aim of this study is to assess the relationship of the TG/HDL ratio with the severity of coronary lesions. Method: This cross-sectional study included 53 acute myocardial infarction patients undergoing coronary angiography. Exclusion criteria include (1) AMI patients receiving fibrinolytic therapy, (2) Patients who have routinely consumed lipid lowering drug for 6 weeks, (3) Incomplete coronary angiography and medical records. The TG/HDL-C ratio is the result of dividing the triglyceride value by HDL. The TG/HDL-C ratio was divided into 2 groups, namely the TG/HDL-C ratio <4 group and the TG/HDL-C ratio >4 group. The severity of coronary lesions was described by the SYNTAX score, which was divided into two: the low SYNTAX score group (≤22) and patients with a low SYNTAX score (≤22) and medium-high SYNTAX score (≥23). Bivariate analysis was performed to find the relationship between the TG/HDL-C ratio and the SYNTAX score. The value of p<0.05 was considered statistically significant. Results: From 53 patients, 26 patients (49.1%) had a SYNTAX score ≥ 23 and 27 patients (50.9%) had a SYNTAX score < 23. Patients with NSTEMI, DM, and obesity were higher in the SYNTAX score group ≥23. There was a significant relationship between the TG/HDL-C ratio with coronary lesion severity (p = 0,004). Conclusion: Elevated of TG/HDL-C ratio > 4 is correlated with coronary lesion severity in acute myocardial infarction patients using the SYNTAX score.