| dc.description.abstract | Diabetes Mellitus (DM) is known as a chronic disorder of carbohydrate (glucose) process of metabolism inside the body and its prevalence that goes higher. Until 2015, 10 million cases of DM were reported in Indonesia and also continue to increase. The Indonesian government encourages people to consume traditional medicines because they remember the low side effects.
Cinnamon (Cinnamomum zeylanicum) contains antioxidants which are able to help reduce the risk of oxidative stress, a condition that is a major factor of risk for several chronic diseases, as like diabetes. Bay leaf (Syzygium polyanthum) also contains flavonoids that can lower glucose levels. Thus, cinnamon and bay leaves have the potential to be products that are beneficial to the community, namely diabetic herbal medicine. The goals of this research was to help determining the cinnamon bark extract and bay leaf extract antidiabetic activity against reducing levels of blood sugar in tested animals.
This study used experimental methods in vivo. Using 28 alloxan-induced male mice were classified into 7 groups: (1) Negative control that has no treatment, then (2) Positive control given metformin 45mg/kgBB, (3) Cinnamon dose 750 mg/kgBB, (4) Bay leaf 750 mg/kgBB, (5) Combination of Cinnamon and Bay Leaf dose ratio 1: 1 (375 mg/kgBB), 1: 2 (250 mg/kgBB and 500 mg/kgBB), and 2:1 (500 mg/kgBB and also 250 mg/kgBB), given orally for 14 days. The results showed a percentage decline inside the levels bof blood sugar during the test obtained Metformin administration 32.27%, cinnamon by 24.52%, bay leaf 21.05%, combination (1: 1) 23.71%, (1: 2) 35.83%, (2: 1) 40.83%. The combination of the two shows a higher and synergistic effect. | en_US |
