Perbedaan Rasio Neutrofil-Limfosit dan Limfosit-Monosit pada Pasien Abortus dan Hamil Normal di RS Jejaring USU

Abstract

Background: Neutrophil-lymphocyte ratio (NLR) has a prognostic value that fulfill the criteria of early abortion. Multivariate analysis also revealed that NLR is the only prognostic variable to predict early abortion. Area under the curve (AUC) value below NLR to differentiate the missed and threatened abortion is 0.792, and the best estimated cut-off value is 5.72 (P<0,05). It means that NLR >5.72 may represent a heightened risk for early abortion, thus immediate treatment is needed for the pregnancy itself. In other hand, higher lymphocyte-monocyte ratio (LMR) is correlated with the lower risk for early threatened abortion in cut-off value of 2.19. This is the first study to evaluate the correlation between LMR and abortion among women with early threatened abortion. As an inflammatory factor, it suggested that LMR has an important role in gestation. Aim: This study aimed to analyzed the difference between NLR and LMR among abortive and pregnant patient in Universitas Sumatera Utara’s partnership hospitals. Methods: This study is an analytic-observational investigation with cross-sectional design to evaluate the difference of NLR and LMR value among 22 abortive women and 22 normal pregnancy women; each group has gestational ages <20 weeks. This study is performed in Universitas Sumatera Utara’s partnership hospitals Results: From this study, it was found that the mean value of NLR among abortive individuals 6.11 + 5.89, whereas in normal pregnancy groups the value was 2.84 ± 1.01. According to the findings, it is found that the abortive groups has significantly higher NLR value (p=0.021). This study also found the LMR value in normal pregnancy groups to be 3.53 ± 0.91 (2.24-5.50), whilst the value in abortive group was 3.32 ± 2.00 (0.63-9.06). However, no statistical difference was found in this analysis (p = 0.336, p > 0.05). Conclusion: According to this investigation and previous studies, it is found that higher NLR value may become a favorable diagnostic marker to assess and investigating abortive pregnancy. This study also found that lower LMR value was found among abortive individuals, though the statistical analysis does not exhibit significant results. Therefore, the LMR value was considered to be unmeaningful in differentiate normal and abortive pregnancy.