Hubungan Polimorfisme BDNF VAL66MET dan Kejadian Trauma Masa Anak pada Orang dengan Skizofrenia Suku Batak

Abstract

Background: Schizophrenia is a severe brain disease with severe and persistent psychotic manifestations accompanied by dysfunction of cognitive and psychosocial variables. Many studies suggest that the etiology of schizophrenia is a combination of genetic and environmental factors. BDNF Val66Met, functional polymorphism is a candidate genetics and childhood trauma is an environmental factor thought to be associated with the incidence of schizophrenia. The purpose of this study was to analyze the relationship between BDNF Val66Met polymorphism and childhood trauma between people with schizophrenia (ODS) Batak tribe and healthy people Batak tribe. Methods: This study is a multivariate comparative analytical study with a case-control design. Blood samples were taken from a total of 200 subjects (n = 100) for each ODS and control group), then BDNF Val66Met allele and genotype identification was carried out using the Polymerase Chain Reaction- Restriction Fragment Length Polymorphism (PCR-RFLP) technique. Results: There was no significant association between the BDNF Val66Met polymorphism allele in ODS and healthy controls with a value of p = 0.107, OR 1.413 IK95% (0.951-2.099). There was no significant association between the BDNF Val66Met polymorphism genotype in ODS and healthy controls of Met/Met vs Val/Val genotypes with p values of 0.063, OR values of 0.486 IK95% (0.227-1.039), Val/Met vs Val/Val with p values of 0.291, OR values of 1.414 IK95% (0.744-3.689). There is a significant relationship between the incidence of childhood in the CM and FD domains with a p value of <0.001, in the CM domain with an OR of 5.096 IK95% (2.473-10.5) and in the FD domain with an OR of 10.778 IK95% (3.135-37.054), in the VIO domain there is no significant relationship of p value of 0.056 with an OR of 4.846 IK95% (1.020-23.028). There was no significant association between Val66Met's BDNF polymorphism and the incidence of childhood trauma, domains CM, FD and VIO, with a p>0.05 value. Conclusions: There was no association between allele and genotype polymorphism BDNF Val66Met between ODS and healthy controls. There is association between CM and FD domain childhood trauma between ODS and healthy controls. There was no association between BDNF Val66Met polymorphism and childhood trauma in ODS and control