Hubungan Kadar Enzim Antioksidan Glutathione Peroxidase (GPX) dengan Kejadian Tumor Mata

Abstract

Background: Eye tumors have a high level of severity and can threaten vision and life. The antioxidant glutathione peroxidase is produced by the body to reduce damage caused by free radicals. Therefore, glutathione peroxidase can be used as a potential biomarker to evaluate the level of oxidative stress and antioxidant status in eye tumor patients. Objective: To determine the relationship between serum glutathione peroxidase levels and the incidence of eye tumors. Materials and Methods: This study used a case-control design as an observational analytic approach. In this study, there were 21 subjects with eye tumors in the study group, and 21 subjects without eye tumors in the control group. Sampling was carried out from August 2022 to December 2022 at the Ophthalmic Clinic of the Reconstructive, Ocuplasty, and Oncology division. Results: The study group had 21 subjects with eye tumors, with the largest group being female subjects, totaling 12 individuals (57.1%). Most subjects in this age group were between 41-50 years old and worked indoors (61.9%). The most common type of malignant tumor in this group was basal cell carcinoma with a percentage of 30%, while the most common types of benign tumors were epidermoid cysts and conjunctival cysts, both with the same percentage of 36.4%. There was a significant relationship between serum glutathione peroxidase levels and patients with eye tumors (p<0.001), with a mean serum glutathione peroxidase level in the group of subjects with eye tumors of 61.68 U/mL. However, there was no significant difference in serum glutathione peroxidase levels between subjects with malignant eye tumors and subjects with benign eye tumors. Conclusion: In the case group, there was a significant relationship between serum glutathione peroxidase levels and eye tumors (p <0.001).