Korelasi Antara Kadar Glutation dan Gejala Positif Negatif pada Laki-Laki dengan Skizofrenia Suku Batak di Rumah Sakit Umum Daerah Dr. Pirngadi Medan

Abstract

Background: Oxidative stress has been a belief as a part of pathophysiological mechanisms of schizophrenia. This stress occurs due to the imbalance of antioxidant and oxidant, by which one of the main antioxidants that contribute crucially in the oxidative-stress preventable mechanism is glutathione. The correlation between the oxidative stress, glutathione deficiency, and schizophrenic pathophysiology has been reported in previous clinical studies. The reduction of glutathione particularly in schizophrenic symptomatology (especially in negative and positive symptoms) has been characterized. Methods: This study is a numeric-numeric correlative-analytical study with cross-sectional study. The study recruited 48 Bataknese males with schizophrenia status who have been administered with atypical antipsychotic medications for at least a year. The determination of glutathione levels was carried out by ELISA Method to calculate the level of GSH concentration within the blood plasm in in vitro. The positive and negative symptoms were characterized via Positive and Negative Syndrome Scale (PANSS). Results: From the results, a p<0.05 was obtain, indicating a significant correlation between the glutathione levels to the positive-negative symptoms of schizophrenia. The Pearson correlation value was -0.587, which was negative value with medium strength of correlation. Conclusion: Our findings have confirmed the oxidative stress as one of the pathophysiological mechanisms of schizophrenia. This study also showed the lower level of glutathione would increase the severity of positive symptoms of Bataknese males with schizophrenia.