Korelasi Antara Kadar Glutathione (GSH) dan Fungsi Kognitif pada Orang dengan Skizofrenia (ODS) di Rumah Sakit Umum Daerah Dr. Pirngadi Medan

Abstract

Background: Cognitive impairment is common in individuals with schizophrenia and is considered as a significant predictor of clinical and functional prognosis. Although cognitive deficits are not prominent diagnostic feature of schizophrenia, they can worsen the patient's condition and reduce their quality of life. In addition, decreased glutathione (GSH) level has been linked to cognitive impairment in healthy individuals, as well as to individuals with other neuropsychiatric disorders, including Alzheimer and Parkinson. This study aims to evaluate association between GSH levels and cognitive function in individuals with schizophrenia. Methods: This study is a correlative analytical study with cross-sectional approach, which assesses the correlation between GSH levels and cognitive function of people with schizophrenia. Consecutive sampling was performed to obtain study participants. A total of 65 individuals (43 men and 22 women) participated in the study. The determination of glutathione levels was carried out by ELISA Method to calculate the level of GSH concentration within the blood plasm in in vitro. MoCA-Ina was used to evaluate the cognitive function. Result: Men comprised the vast majority of individuals with schizophrenia in this study (66.15%), the highest level of education is high school (75.38%), and majority of participants are not married (72.30%). 72.30% are jobless, and majority of participants are Bataknese (78.46%). The median age is 34 years (20-40 years), median PANSS score is 65 (s 60-73), median length of illness is 4 years (2-10 years), and median glutathione level was 9.00 μg/ml. There was a significant strong positive correlation (p <0.001) between glutathione levels and cognitive function in individuals with schizophrenia, suggesting that lower glutathione level is correlated with lower cognitive function score in individuals with schizophrenia. Conclusion: Glutathione level is proportionally correlated with cognitive function in individuals with schizophrenia.