Hubungan Ekspresi Imunohistokimia CD 31 dengan Subtipe Histopatologi, Lymphovascular Invasion dan Angiogenesis pada Papillary Thyroid Carcinoma

Abstract

Background

Thyroid carcinoma is a malignancy of the thyroid gland originating from thyroid follicular or parafollicular cells. Incidence increases slowly and is relatively rare, accounting for about 1% of all-body malignancies. Papillary thyroid carcinoma (PTC) is most closely associated with radiation. The incidence of thyroid cancer is strongly influenced by many factors including geographic variation, age, and gender. Lymphovascular invasion (LVI) has been recognized as an independent predictor of lymph node metastasis and has been an independent predictor of overall survival. Angiogenesis is the process of formation of new blood vessels that occurs and is very important in the process of growth and development. Estimating the presence of an angiogenesis approach is done by microscopically estimating the microvessel density (MVD) of tumor tissue through immunohistochemical examination of CD31. Increased MVD has been associated with a worse prognosis as an endothelial marker used to calculate MVD, one of which is by using CD31

Method

Analytical studiescross sectionalwith 32 samples diagnosed with PTC from the Anatomic Pathology Una, H. Adam Malik Hospital, Medan.MVDis the number of small blood vessels in terms of size and diameter (arterioles and venules) with round lumens that are stained positively with CD31 categorized into low (1-9 blood vessels/'10 LPB), moderate (10-19 blood vessels 10 LPB) and high (20 vessels/10 LPB). The association of CD31 immunohistochemical expression with histopathological subtypes, LVI and angiogenesis were analyzed by Eta and Somers'd test.

Results There was a significant relationship between CD31 and histopathological subtypes (p=0.05),

lymphovascular invasion and angiogenesis with p-0.01 (p-value<0.05).

Conclusion

MVD significantly associated with histopathological and lymphovascular subtypes.