Hubungan Ekspresi Imunohistokimia Vitamin D Receptor (VDR) dengan Tumor-Associated Stromal Cells (TASCs) dan Grading Histopatologi Adenokarsinoma Prostat

Abstract

Background: In few studies, the exposure of ultraviolet and vitamin D serum levels has been linked to prostate cancer. To date, there are controversy about research results and still no studies linking VDR directly with TASCs in prostate cancer. Objective: To assess the relationship between immunohistochemical expression of VDR with TASCs and histopathological grading in prostate adenocarcinoma. Materials and Methods: This analytic study with cross sectional approach used 35 samples from paraffin blocks from patients histopathologically diagnosed as prostate adenocarcinoma. Grading of these samples were assessed and Masson’s trichrome histochemistry (for TASCs) and VDR immunohistochemical staining were perfomed. All results were analyzed using Chi Square or Pearson chi square. Results and Discussion: There was statistically significant relationship between immunohistochemical expression of VDR with histopathological grading and grade group, with moderate strength value (r=0.381) and p value <0.05. But, no statistically significant relationship between immunohistochemical expression of VDR and TASCs in prostate adenocarcinoma. Conclusion: Further studies are needed to compare vitamin D blood levels with immunohistochemical expression of VDR in prostate tissue. Also, further researchers are needed to relate TGFβ with TASCs and immunohistochemical expression of VDR in prostate adenocarcinoma. In these samples, it is also necessary to further investigate the VDR SNP gene.