| dc.description.abstract | Background: In few studies, the exposure of ultraviolet and vitamin D serum
levels has been linked to prostate cancer. To date, there are controversy about
research results and still no studies linking VDR directly with TASCs in prostate
cancer.
Objective: To assess the relationship between immunohistochemical expression
of VDR with TASCs and histopathological grading in prostate adenocarcinoma.
Materials and Methods: This analytic study with cross sectional approach used
35 samples from paraffin blocks from patients histopathologically diagnosed as
prostate adenocarcinoma. Grading of these samples were assessed and Masson’s
trichrome histochemistry (for TASCs) and VDR immunohistochemical staining
were perfomed. All results were analyzed using Chi Square or Pearson chi square.
Results and Discussion: There was statistically significant relationship between
immunohistochemical expression of VDR with histopathological grading and
grade group, with moderate strength value (r=0.381) and p value <0.05. But, no
statistically significant relationship between immunohistochemical expression of
VDR and TASCs in prostate adenocarcinoma. Conclusion: Further studies are
needed to compare vitamin D blood levels with immunohistochemical expression
of VDR in prostate tissue. Also, further researchers are needed to relate TGFβ
with TASCs and immunohistochemical expression of VDR in prostate
adenocarcinoma. In these samples, it is also necessary to further investigate the
VDR SNP gene. | en_US |
