| dc.description.abstract | Background: Autonomic dysfunction is one of the non-motor symptoms (NMS) in
Parkinson's disease that can occur approximately 5-20 years earlier than the onset of motor
symptoms. Autonomic dysfunction spanning the domains of urinary, gastrointestinal,
sexuality, cardiovascular, pupilomotor and thermoregulation all of which have an impact on
the quality of life of patients, an increasing number of clinical studies have appeared in
recent years.
Objective : To determine relationship of autonomic dysfunction, duration of diasease and
treatment with severity of parkinson’s disease.
Methods: This study used a cross-sectional design of Parkinson's patients who were treated
at the Neurology Polyclinic of RSUP. Hajj Adam Malik Medan and Network Hospital in
January -May 2023. Diagnosis according to United Kingdom Parkinson's Disease (PD)
Society Bank's Clinical Criteria. Autonomic dysfunction was assessed using the Scales for
Outcomes in PD for Autonomic Symptoms questionnaire, Parkinson's severity using the
Unified Parkinson's Disease Rating Scale.
Results: From the 37 study subjects the majority were male (56.8%), mean age 67.38 years,
high school education, most jobs were housewives, ethnic Batak, the majority of subjects had
no family history of Parkinson's disease. Hypertension is the most comorbid. Most are in
stage I (32.4%). Having a disease duration of 2 – < 11 years, approximately 54.1% had
taken medication for < 5 years and most received a Levodopa combination drug (97.3%).
There is a significant relationship between autonomic dysfunction and the severity of
Parkinson's disease (p <0.001) with (r= 0.814), There is a relationship between the
duration of the disease and the length of treatment with the severity of Parkinson's (p
<0.001) with( r = 0,820) dan ( r = 0,764).
Conclusion: There is a positive correlation of autonomic dysfunction, disease duration and
treatment with the severity of Parkinson's disease. | en_US |
