Penyediaan Hidrogel Berbasis Selulosa Bakteri/ Polivinil Alkohol-Mikroenkapsulasi Ekstrak Daun Kemuning (Murraya paniculata (L.) Jack) Berpotensi sebagai Bahan Material Pembalut Luka

Abstract

The development of traditional wound dressings such as gauze into modern hydrogel wound dressings is currently being developed. Hydrogel based on SB/PVAMEDK which has the potential as a wound dressing material has been successfully prepared using the chemical crosslinking method with variations of PVA 0, 1, 3, 5, 7, and 9%. Where the manufacture of SB/PVAMEDK hydrogel went through 4 stages, namely making Kemuning leaf extract, making microencapsulation of Kemuning leaf extract, making SB/PVA hydrogel, and impregnation of SB/PVA hydrogel into microencapsulation of Kemuning leaf extract. Kemuning leaf extract was tested for phytochemicals with the results of the presence of alkaloids and flavonoids. Kemuning leaf extract and microencapsulation of kemuning leaf extract were tested for their antibacterial ability which showed strong category inhibition of Staphylococcus aureus and Escherichia coli bacteria. The microencapsulation of the kemuning leaf extract was tested in the yielding mass with a yield of 0.35 g, the recovery yield was 33.3%, the PSA distribution showed a mean of 1.00132 [μm], the microencapsulation morphology of the kemuning leaf extract was coarse and porous, FT-IR indicated the presence of OH groups, NH, C=O, and PO2. Furthermore, the hydrogel obtained was then subjected to swelling, cross-linking, and antibacterial tests, then characterized through tensile strength, FT-IR, SEM, XRD, and TGA tests. The results showed that the SB/PVAMEDK hydrogel had swelling that met the minimum standards for wound dressings, namely hydrogels with PVA concentrations of 0, 1, 3, and 5%. It was also found that hydrogels at PVA concentrations of 0, 1, 3, and 5% had very strong antibacterial properties, and those at PVA concentrations of 7 and 9% were categorized as strong. However, the SB/PVAMEDK hydrogel at PVA concentrations of 0, 1, and 3% had poor mechanical properties. While the results of the spectrum with FTIR indicated that cross-linking had occurred in all hydrogels which was indicated by the presence of bands at wave numbers 1714 cm-1 and 1050 cm-1 indicating the presence of ester bonds. The SEM results showed that the surface morphology of the hydrogel looked uneven. The decomposition temperature of the hydrogel is 400-600 oC. So, it can be concluded that the SB/PVA5%MEDK hydrogel is a more appropriate hydrogel to be used as a wound dressing material.