Pengaruh Indeks Resistensi Eritropoietin terhadap Mortalitas pada Pasien Hemodialisis Reguler di RSUP Haji Adam Malik Medan

Abstract

Introduction:One of the functions of the kidneys is the production of erythropoietin, a signaling molecule that stimulates the production of red blood cells, in response to reduced oxygen levels in the blood. In chronic kidney disease there is a disturbance in the production of erythropoietin. Several previous studies have linked the index of erythropoietin resistance to mortality in patients with chronic kidney disease. However, research in Indonesia is still limited. Method: Observational analytic study with a cross-sectional method to assess the relationship between the erythropoietin resistance index and mortality in regular hemodialysis patients at Haji Adam Malik General Hospital Medan. The erythropoietin resistance index was used to evaluate EPO by comparing the dose of EPO to the hemoglobin level. The data was tested statistically with the Chi Square method. Results: The average study subjects suffered from anemia with Hb levels of 8.21 g/dL, serum iron levels of 63.22 mcg/dL, increased TIBC levels with an average value of 190.2 mcg/dL, low ferritin levels of 195.59 mcg/L, serum transferrin (TSAT) levels. ) was low with an average of 19.2%, and albumin levels were low with an average of 2.94 g/dL. Albumin levels, transferrin saturation and erythropoietin resistance index were associated with the mortality rate of patients undergoing regular hemodialysis (p=0.021; p=0.011; p=0.012). Conclusion: There is a relationship between the index of erythropoietin resistance and the mortality rate of patients undergoing regular hemodialysis