Neutrofil Limfosit Rasio sebagai Biomarker Dini Infeksi Luka Operasi pada Pasien yang Telah Menjalani Operasi Tulang Belakang yang Dirawat di RSUP H. Adam Malik Medan

Abstract

Background: Surgical wound infection is one of the most common nosocomial infections that occurs after surgery. The incidence rate of ILO in the surgical stage is quite high, especially in orthopedic surgery, the incidence can be up to 71%. Surgical site infection after spine surgery usually occurs through direct inoculation during the surgical procedure. The use of blood culture and wound culture as the gold standard also has several obstacles. Due to the above constraints, an alternative marker is needed that can diagnose early ILO events. One marker that can be used is the neutrophil-lymphocyte ratio. The use of the neutrophil-lymphocyte ratio is relevant and consistent with the pathogenesis of ILO. Methods: This research is an observational study with a retrospective data collection method. This study took blood samples from patients who had undergone spinal surgery as many as 60 patients. Sample checked for NLR on postoperative day 5. Analyze the sensitivity, specificity and cut off values of NLR as an early biomarker of ILO in patients who have undergone spinal surgery Results and Discussion: This study was attended by 60 spinal post-op patients who were treated at H. Adam Malik General Hospital Medan from November 2021 - January 2022. The number of patients who were male was 29 people (48%). and female patients totaling 31 people (51%). The mean age of the subjects was 52 years. The Spearman correlation test shows that there is a significant relationship between NLR and ILO with sufficient correlation strength. the average NLR of 10.10 with a standard deviation of 5.27 is obtained by a value of r > 0.497 with a value of p <0.0005. Conclusions and suggestions: There is a significant relationship between NLR and ILO. Further research is needed involving a larger number of subjects, NLR is connected with other imaging tests such as MRI to strengthen the early detection of ILO or with culture.