Hubungan Kadar Serum Bilirubin Total dan Fibrinogen dengan Tingkat Keparahan Stroke Iskemik Akut

Abstract

Background Of all neurological diseases that can arise in adulthood, stroke is in the first position in the level of frequency. Many scales are available to measure stroke severity, including the National Institutes of Health Stroke Scale (NIHSS). NIHSS is the most widely used deficit assessment scale in modern neurology. It is known that there are several laboratory markers that can affect the severity of acute ischemic stroke, including serum levels of total bilirubin and fibrinogen. Purpose To determine the relationship between serum levels of total bilirubin and fibrinogen with the severity of acute ischemic stroke. Method This research is analytical with cross-sectional data collection method. Sampling was carried out in the inpatient room of RSUP H. Adam Malik Medan. The study sample was taken as many as 40 subjects with a nonrandom sampling method consecutively. Data analysis using Chi Square test. Result The majority of subjects had an average age of around 56.5 years, with the most age group aged 51-60 years (32.5%). The gender of the study subjects was mostly male (60%), educational background, mostly had high school education (40%), and occupation, most are self-employed (30%). Based on bivariate analysis tests, there was a significant relationship between total serum bilirubin levels and the severity of acute phase ischemic stroke (p = 0.009; r = 0.382). There was also an effect of serum fibrinogen levels on the severity of acute phase ischemic stroke (p = 0.028; r = 0.328). Conclusion Serum levels of total bilirubin and fibrinogen affect the severity of acute ischemic stroke.