| dc.description.abstract | Background: Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used as an analgesic and anti-inflamatory. Based on the Biopharmaceutical Classification System (BCS), ibuprofen is categorized in class 2 because it has low solubility in water and high permeability, so it is necessary to the existence of a formulation that can increase the bioavailability to achieve the optimum therapeutic effect Objective: To formulate niosom with surfactant variation using ibuprofen as a drug model and evaluate the effect of surfactant variation on the characterization of niosom. Method: The niosom were formulated along with non-ionic surfactant by an emulsion evaporation method. The composition of the niosom formulation with different of surfactant variation such as F1 based on Tween 80, F2 based on Span 40 and F3 based on combination of Twen 80 and Span 40. Characterization of niosom was carried out included analysis particle size, polidispersity index (PdI), zeta potential, morphology, %encapsulation efficiency and stability. Results: The particle size niosom F1, F2 and F3 respectively 48,7 ± 0,301 ; 263,833 ± 2,003 and 133,933 ± 1,320 nm, PdI values of F1, F2 and F3 respectively 0,180 ± 0,016 ; 0,213 ± 0,015 and 0,168 ± 0,012. The zeta potential of F1, F2 and F3 respectively -15,2 ± 1,229 ; -28,767 ± 0,306 and -20,3 ± 0,764. The morphology showed that the niosom were spherical type in shape. %Encapsulation Efficiency of formulation F1, F2, F3 were 41,9%, 81,8% and 67,7%. Niosom did show a significant increase the particle size during 1 month storage period. Conclusion: The niosom is successful prepared by an emulsion evaporation method. Niosom formulation F2 based on the non-ionic surfactants (Span 40) exhibited the maximum entrapment of ibuprofen (81,7%). The niosom were not stable during month of storage. | en_US |
