Uji Efektivitas Antiinlamasi Pasta Ekstrak Lidah Buaya (Aloe Vera L) pada Luka Soket Pasca Pencabutan Gigi Tikus Putih Galur Wistar Berdasarkan Jumlah Makrofag

Abstract

Wounds that occur due to tooth extraction and surgery will undergo a wound healing process. Wound healing stages are divided into 3 phases, namely inflammation, proliferation and remodeling. Inflammation is a protective mechanism of the body that seeks to neutralize and eradicate harmful agents in the injured area and prepares for tissue repair. Macrophages are the most dominant cells in inflammation with the highest number on the 3rd day and are distributed in most of the connective tissue. Aloe vera (Aloe vera L) is one of the herbal plants that can help the inflammatory process. This study aims to determine the anti-inflammatory effectiveness of aloe vera paste extract (Aloe vera L) with concentrations of 25%, 50%, and 75% on the number of macrophage cells in socket wounds after tooth extraction in Wistar white rats. The samples used were 48 rats that had been acclimatized and then the teeth of Wistar rats were extracted on the left incisor of the lower jaw then aloe vera paste extract (Aloe vera L) was applied with concentrations of 25%, 50% and 75% in the treatment group and basic paste administration. In the control group, tissue samples were taken using Hematoxylin Eosin (HE) examination to see the number of macrophage cells. Data processing was analyzed using the Shapiro Wilk test followed by a one way ANOVA test. The results showed that there was a significant average difference in the number of macrophages produced by each negative control group with basic paste administration and the treatment group with Aloe vera extract (p<0.05). The conclusion of this study is that aloe vera paste extract (Aloe vera L) with concentrations of 25%, 50%, and 75% has an anti-inflammatory effect on decreasing the number of macrophage cells in post-tooth extraction socket wounds. This research is a laboratory experimental study with a post test only control group research design.