| dc.description.abstract | Background: Colorectal cancer is the third most common cancer in which data from the Global Cancer Observatory (GLOBOCAN) reported 1,931,590 new cases in 2020. Several studies had reported important CEA role as a biomarker in the diagnosis, treatment and evaluation of disease in colorectal cancer. High levels of CEA in the pre operative period predict an unsuccessful outcome, while high levels in the postoperative period are the first clue of local or distant recurrence.
Methods: This research is an analytical study with a cross sectional design which was carried out once, there was no follow up. This study aims to determine the relationship between Carcinoembryonic Antigen (CEA) value and clinical charactheristics in young colorectal cancer patients (≤ 50 years) at Haji Adam Malik General Hospital Medan.
Results: According to the location, the colorectal cancer of 32 patients was located in the rectum. According to the degree of differentiation, the majority of patients were well differentiated cancer, namely 30 patients or 65.2%. According to the staging, most of the patients came with stage 3B, namely 18 patients or 39.1%. CEA examination was carried out on all study samples. The average CEA value was 47.43 ng/mL with a standard deviation of 76.2 ng/mL.
Conclusions: There is a relationship between CEA and the degree of differentiation of colorectal cancer where if the value of CEA increases, the degree of differentiation will lead to poorly differentiated but a similar relationship is not found based on location and staging | en_US |
