Hubungan Ekspresi Imunohistokimia Matrix Metalloproteinase-9 (MMP-9) dengan Tumor Budding Peritumoral dan Subtipe Molekuler pada Invasive Breast Carcinoma of No Special Type

Abstract

Background : Breast cancer ranks first most often in the world in 2020, is a malignant cancer that often occurs in women. Matrix metalloproteinase-9 (MMP- 9) has been the focus of attention in several previous studies in the field of breast cancer, which plays a role in extracellular matrix remodeling. High expression of MMP-9 is associated with tumor aggressiveness, metastatic potential and poor prognosis Objective : This study was conducted to analyze the association of MMP-9 immunohistochemical expression with peritumoral budding tumors and molecular subtypes in invasive breast carcinoma of no special type (IBC-NST). Material and Methods : This study is an analytic study with a cross sectional approach on 41 samples of paraffin block cases of IBC-NST which had been diagnosed histopathologically and then performed with MMP-9 immunohistochemical staining. The data obtained in the study were processed with the help of statistical software. Statistical analysis between MMP-9 expression with peritumoral tumor budding and molecular subtypes was performed using the Somers'd and Eta tests. Result : MMP-9 expression was significantly associated with peritumoral budding tumors (p = 0.0001) and also with molecular subtype (p < 0.05) Conclusion: MMP-9 can be used as a prognosis and in combination with molecular subtypes in breast cancer can be a specific biomarker.