| dc.description.abstract | Background: Improper pain management in postoperative patients can increase
complications in the respiratory, metabolic, and infectious systems, which in turn
lead to increased patient morbidity and mortality. In postoperative patients in the
ICU, not only analgesics are needed but also sedation so that the patient can remain
calm during treatment, especially patients with mechanical ventilation. The use of
subdose ketamine instead of fentanyl and midazolam as sedative analgesic agents
can be done by using the measurement parameters of the quantium consciousness
index (qCON) and quantium noxious index (qNOX) in measuring the depth of
sedation and adequacy of analgesics as a new alternative to nociceptive monitoring
methods with more objective results.
Objective: Obtain results of comparing qCON and qNOX in postoperative patients
by administering subdose ketamine compared to a combination of fentanyl and
midazolam in RSUP Haji Adam Malik Medan.
Methods: The research design is randomized clinical trial with a double-blind
method. After obtaining approval from the Ethics Committee of the Faculty of
Medicine, Universitas Sumatera Utara, Medan, 44 research samples were collected
which, after fulfilling the inclusion criteria, were randomly divided into 2 groups.
Group A received a subdose of ketamine and group B received a combination of
fentanyl and midazolam. The research data obtained were tested using SPSS.
Results: There were differences in the median, minimum and maximum values of
qCON and qNOX in the groups given subdose ketamine and fentanyl and
midazolam but these were not statistically significant (p > 0.05) at T0, T1 and T2.
Conclusion: Administering a subdose of ketamine can provide sedation and
analgesia comparable to those of fentanyl and midazolam. | en_US |
