| dc.description.abstract | Introduction: Craniotomy surgery can increase the body's inflammatory response by
provoking a neuroendocrine stress response by activating the hypothalamic-pituitaryadrenal
(HPA) axis and sympathetic nervous system, which significantly increases serum
adrenocorticotropic hormone (ACTH), cortisol, and serum catecholamine levels.
Interleukin-6 as one of the inflammatory parameters has a close relationship with
inflammation after craniotomy surgery. Combination fentanyl with midazolam and
dexmedetomidine as anelgesia drugs have the role of inhibiting inflammatory regulation
to reduce the release of inflammatory mediators including Interleukin-6.
Objective: To compare the results of Combination fentanyl with midazolam and
dexmedetomidine administration on interleukin-6 levels in post-craniotomy patients in the
ICU room.
Methods: This study is an experimental study with The Pretest-Posttest Control Group
Design, with a double blind randomized controlled trial (RCT) clinical trial where in this
study two groups were divided. After obtaining approval from the Ethics Committee of the
Faculty of Medicine, University of Sumatera Utara Medan, 32 research samples were
collected, which after meeting the inclusion criteria were randomly divided into 2 groups.
Group A received a combination of Fentanyl and Midazolam and group B received a
combination of Dexmedetomidine. The data obtained were tested using SPSS.
Results: There was a decrease in the mean value of interleukin-6 levels in Combination
fentanyl with midazolam administration group and the Dexmedetomidine administration
group, but statistically did not provide a significant value between the two groups.
Conclusion: Combination fentanyl with midazolam and Dexmedetomidine administration
have comparable effects in reducing Interleukin-6 levels. | en_US |
