Korelasi Nilai Limfosit terhadap Titer Antibodi Netralisasi SARS-COV-2 pada Residen Penyakit Dalam Fakultas Kedokteran Universitas Sumatera Utara yang sudah Mendapatkan Vaksinasi Covid-19

Abstract

Introduction: Corona virus disease-19 (COVID-19) is a respiratory disease caused by SARS-COV-2 virus (Severe acute respiratory syndrome-Coronavirus 2). Almost all of the COVID-19 vaccines were designed to produce neutralizing antibody towards the spike (S) protein of the SARS-COV-2 virus. In the formation process of the antibody, the lymphocyte value has been known to be one of the important parameters to evaluate the effectiveness of the vaccine. This research was conducted to assess the correlation between the lymphocyte value and the neutralizing antibody titer in residents of internal medicine in Faculty of Medicine, Universitas Sumatera Utara, who had received COVID-19 vaccination. Method: This research was an observational analytic study with cross-sectional design, conducted since February to May 2022. The research was performed on residents of internal medicine in Faculty of Medicine, Universitas Sumatera Utara, who had received COVID-19 vaccination. All subjects were then interviewed about their health information and previous comorbidity. Blood samples were drawn for lymphocyte and neutralizing antibody examination that was carried out in Prodia-Medan Laboratory. The lymphocyte value was based on the complete blood count, while the neutralizing antibody titer was based on the IgG-SARS-COV-2 titer that was measured using chemiluminescent immunoassay. The data was collected and analyzed using SPSS version 26. Results: There were a total of 45 research subjects included in the study, with a range of age mostly between 26-30 years (64.4%) consisted of 19 men (42,2%) and 26 women (57.7%). The mean value of body mass index was 24.14± 5.56 kg/m2. The mean value of lymphocyte was 31.28% with a mean value of absolute lymphocyte count (ALC) of 2437.99. The mean value of IgG-SARS-COV-2 was 13864.44 AU/ml. History of positive COVID-19 previously was found in 37 subjects (82.2%). The correlation test between lymphocyte value and IgG-SARS-COV-2 titer using Spearman correlation showed a p-valued of 0.476. Conclusion: There was no significant relationship found between the lymphocyte value and the neutralizing antibody titer in residents of internal medicine in Faculty of Medicine, Universitas Sumatera Utara who had been vaccinated (p-value 0.476).