| dc.description.abstract | Acne is a skin disorder due to inflammation that is accompanied by blockage of
theducts of the skin and hair oil glands (pilosebaceous ducts), which are characterized
by thepresence of comedones, papules, and pustules. Staphylococcus epidermidis and
Propionibacterium acnes are the main bacteria that cause acne by producing lipases that
break down free fatty acids from skin lipids. The principle of therapy in the treatment
ofacne is reducing excess sebum production. The purpose of this study was to formulate
a nanogel preparation from the ethanol extract of lime peel as an anti-acne agent.
The ethanol extract of lime peel was obtained by the immersion maceration
methodusing 96% ethanol, then screening tests and characterization of the simplicia
and extractwere carried out. Base nanogel and ethanol extract was formulated into
nanogel preparations witha concentration of 5% (F1), 6% (F2), and 7% (F3), which
were further characterized by the physical characteristics of the preparation, stability
by storing the preparation for 12 weeks, irritation, and testing the effectiveness of the
preparation in vitro. In addition, nanogel preparations were also tested for their
effectiveness against Propionibacterium acnes and Staphylococcus epidermidis
inhibition.
The results of the phytochemical screening of lime peel extract positively
containedalkaloids, flavonoids, glycosides, saponins, tannins, and steroids and fulfilled
all the characterization requirements for simplicia. Lime peel ethanol extract was
formulated into a nanogel preparation with a concentration of 5, 6, and 7%, which met
the physical characteristics of the preparation, was stable for 12 weeks of storage, and
did not cause irritation to the skin of the tested volunteers. The results of the lime peel
extract nanogeltest showed activity in inhibiting the growth of Propionibacterium acnes
and Staphylococcus epidermidis bacteria, and the 7% nanogel formula was an effective
formula in inhibiting bacterial growth.
Based on the results of the study, it can be concluded that the nanogel preparation
of lime peel ethanol extract is stable at 12 weeks of storage and 7% ethanol extract is a
formula that has the most effective antibacterial and anti-acne activity | en_US |
