Efek Terapi Awal Obat Anti Tuberkulosis terhadap Rasio Neutrofil Limfosit pada TBC Paru Anak sebagai Indikator Keberhasilan Terapi

Abstract

Background. Tuberculosis (TBC) remains a major threat to health, especially in children, and there are several difficulties in assessing both diagnosis and the success of therapy. The neutrophil to lymphocyte ratio (RNL) is a biomarker that is easy to obtain, and does not require costs. Objective. To determine the effect of initial TBC therapy on RNL. Method. Quantitative study with descriptive analytical research design with a cohort retrospective approach. The data is secondary data in the form of medical records of pediatric pulmonary TB patients at RSKP Medan 2022-August 2023. Patient characteristics, number of leukocytes, neutrophils and lymphocytes as well as RNL were recorded and analyzed using SPSS. Results. There were 75 samples, of which 43 (57.3%) were male with a median age of 6 years. The average RNL before therapy (2.2) was higher than the RNL after initial TBC therapy (1.23) (p=0.000). Conclusion. There was a statistically significant decrease in the ratio of neutrophils to lymphocytes in pediatric pulmonary TBC patients after initial TBC therapy.