Hubungan Antara LDH, SGPT, SGOT, Bilirubin, dan Trombosit dengan Kejadian Proteinuria pada Pasien Preeklamsia Berat di Rumah Sakit Haji Adam Malik Medan

Abstract

Background: Preeclampsia is a cause of morbidity and mortality in pregnant women, ranking third as a cause of maternal death in Indonesia. Preeclampsia is a syndrome that occurs during pregnancy, characterized by elevated blood pressure and the presence of protein in the urine. The disease is marked by worsening conditions, including hemolysis, elevated liver function, and thrombocytopenia. Early detection of preeclampsia is closely related to proteinuria. Objective: To identify the relationship between LDH, bilirubin, SGPT, SGOT, and platelets with proteinuria in severe preeclampsia patients. Method: This research uses a quantitative approach with a retrospective analytical design and a cross-sectional method with chi-square and Fisher’s exact tests. The data used in this study are secondary data taken from the medical records of patients diagnosed with Severe Preeclampsia at Haji Adam Malik Central General Hospital in Medan from January 2020 to March 2023. Results: The highest incidence was found in pregnant women aged 20-35 years. It was found that 74.3% of the population had semiquantitative urine protein levels ≥+2. The average levels of LDH, total bilirubin, SGPT, SGOT, and platelets were 514.64 U/L, 0.9 mg/dL, 57.77 U/L, 64.01 U/L, and 197,585/mm3, respectively. Statistical analysis showed a significant relationship between proteinuria and LDH (p 0.001). However, there was no significant relationship between liver function and platelets with proteinuria. Conclusion: There is a relationship between LDH and proteinuria in severe preeclampsia patients.