| dc.description.abstract | Introduction. The prevalence of oral candidasis increases in patients with type 2
diabetes mellitus especially if uncontrolled (HbA1C≥7%). This occurs due to
dysbiosis and changes in oral microbes, especially Candida sp. Several studies
have shown that binahong plant extract has activity as an antifungal on Candida
sp. Objective. To determine the antifungal effectiveness of binahong leaf extract
mouthwash preparation against the growth of Candida sp. colonies in the oral
cavity of uncontrolled type 2 diabetes mellitus patients. Methods. This study used a
true experimental method with a group pretest-posttest control design. Data were
obtained from the Candida sp. colonies counting in saliva samples of uncontrolled
type 2 diabetes mellitus patients (HbA1C≥7c) which were divided into 2 groups, the
treatment group given a mouthwash preparation of binahong leaf extract (Anredera
cordifolia (Ten.) Steenis) using a concentration of 12.5%. and the control group
using aquades. Results. Of the 32 samples, there was an increase in the growth of
Candida sp. colonies in the oral cavity (≥400 cfu/ml) during the pre test in 19
samples, 9 samples (56,3%) in the control group and 10 samples (62,5%) in the
binahong group while during the post test the was an increase in 16 samples, 10
samples (62,5%) in the control group and 6 samples (37,5%) in binahong group.
Based on the results of statistical analysis, there was a significant decrease in
Candida sp. colonies before and after giving 12.5% binahong leaf extract
mouthwash (p-value <0.001) and there was a significant difference between giving
12.5% binahong leaf extract mouthwash and aquades (p-value <0.001).
Conclusion. Binahong (Anredera cordifolia (Ten.) Steenis) leaf extract mouthwash
preparation can reduce the growth of Candida sp. colonies in the oral cavity in
uncontrolled type 2 diabetes mellitus patients. | en_US |
