Hubungan Kadar Interleukin-6 dan Profil Lipid pada Wanita Usia Menopause dengan Wanita Usia Reproduktif yang Mengalami Penyakit Jantung Koroner di RSUP. H. Adam Malik

Abstract

Introduction: Menopause causes changes in the lipid profile by increasing total cholesterol, triglycerides, LDL cholesterol and VLDL cholesterol, and decreasing HDL. In women with cardiovascular risk associated with plasma levels of IL-6 and CRP. Specifically, age, BMI, smoking history, blood pressure, alcohol use, diabetes, and exercise frequency were correlated with IL-6 concentrations. The aim of this study was to determine the relationship between IL-6 levels and Lipid Profile in menopausal and reproductive women with Coronary Artery Disease. Methods: Observational analytical study with a case-control design was used in this study. Two groups (menopausal and reproductive women) amount forty-four womens had their IL-6 levels and Lipid Profile checked. The data was then analyzed using a correlation test. Results: A significant relationship was found between the group of menopausal women and the group of reproductive women in terms of Body Mass Index, smoking habits, and family history of heart disease (p<0.05). There was a significant correlation between IL-6 levels and lipid parameters, including Total Cholesterol, LDL, and Triglycerides (p<0.05) in both groups. Meanwhile, HDL levels between the two groups were not statistically significant (p>0.05). In the group of menopausal women, there was a significant relationship between the duration of menopause and IL-6 levels (p<0.05). Conclusion: There was a significant relationship between IL-6 levels and Lipid Profile (Total Cholesterol, LDL, and Triglycerides) in menopausal women and reproductive women with Coronary Artery Disease.