| dc.description.abstract | Background: Striae distensae (SD) or stretch marks still present challenges in
treatment. Papaya (Carica papaya L.) is a plant that is widely cultivated and has many
benefits in Indonesia. Papaya seeds contain alkaloids, saponins, flavonoids and tannins
which play a role in repairing striae distensae through anti-inflammatory mechanisms
as well as increasing fibroblast activity and collagen production which plays a role in
improving wound healing.
Objective: To determine the effect of 4% papaya (Carica papaya L.) seed extract
cream on striae distensae.
Subject and Methods: This study is a quasi experimental clinical trial with a pretestpostest
research design on 30 subjects with striae distensae. Diagnosis was confirmed
by history and clinical evaluation using the Imam, Nelva, Alviera score (INA score)
before and after administration of 4% papaya seed extract cream on femuralis region
and combination of 4% papaya seed extract cream and 0,1% tretinoin cream on gluteus
region at week 0, 2, 4, 6, and 8. Adverse effects were recorded during the study and
satisfaction levels were assessed at the end.
Results: The majority of subjects ages ranged from 18-25 years (83.3%). There was a
significant decrease in INA scores in striae distensae, both after being given 4% papaya
seed extract cream or combined with 0.1% tretinoin cream for 8 weeks (p<0.001). In
striae distensae after being given 4% papaya seed extract cream compared with 4%
papaya seed extract cream combined with 0.1% tretinoin cream, there was no
significant difference (p>0.05). Of the total 30 subjects, none experienced side effects.
Based on the level of satisfaction, all subjects feel satisfied.
Conclusion: The use of 4% papaya seed extract cream can improve the appearance of
striae distensae without side effects and the all subjects feel satisfied. | en_US |
