Perbandingan Perubahan rSO2 pada Sedasi Midazolam dan Propofol Pasca Kraniotomi di ICU RSUP H. Adam Malik

Abstract

Background: Cerebral Regional Oxygen Saturation (rSO2) reflects tissue perfusion in the cerebrum. Decreased rSO2 is associated with cognitive dysfunction and length of hospital stay. Midazolam and propofol can decrease Cerebral Blood Flow through decreasing the cerebral oxygen metabolic rate. Objective: To analyze the comparison of changes in rSO2 after midazolam and propofol administration in post-craniotomy patients in the ICU of Haji Adam Malik General Hospital Medan. Methods: This is a randomized control trial study. Patients were divided into, (1) Midazolam group, given sedation with an initial dose of 0.05 mg/kg followed by a maintenance dose of 0.02 - 0.10 mg/kg/hour and (2) Propofol group given sedation with a dose of 0.3 - 3mg/kg/hour, with the target of the 2 groups being a RASS value of 0 to -2. Data analysis using unpaired T test. Results: Based on the results of the analysis, all characteristic data found no significant differences between groups so as not to affect the parameters to be assessed. The results of the analysis of rSO2 and RASS between groups showed statistically significant differences in right and left rSO2 (p<0.001), but there was no significant difference in RASS (p>0.05) between each group at each measurement time. The results of the analysis of rSO2 and RASS between times, there was no statistically significant difference in right and left rSO2 (p>0.05), but there was a statistically significant difference in RASS (p<0.001) at each measurement time. Based on the results of the analysis carried out, it is known that there is no statistically significant difference in changes in rSO2 both right and left and in changes in RASS because it is found that all data have p>0.05. Conclusion: There is no change in right and left rSO2 and RASS after administration of propofol and midazolam groups in post-craniotomy patients in the ICU of Haji Adam Malik General Hospital Medan.