Hubungan Usia Onset, Frekuensi Kejang dan Durasi Penyakit terhadap Fungsi Kognitif Pasien Epilepsy di Poliklinik Neurologi Rumah Sakit Umum Pusat Haji Adam Malik Medan

Abstract

Background. Cognitive function disorders often occur in individuals with epilepsy. The decline in cognitive function in epilepsy patients can be caused by various factors, including age of onset, seizure frequency, and duration of the disease. Objectives. This study aims to investigate the relationship between the age of onset, seizure frequency, and disease duration on the cognitive function of epilepsy patients at the Neurology Outpatient Clinic of Haji Adam Malik General Hospital in Medan. Methods. This research is an observational cross-sectional analytic study. Data were obtained through interviews with epilepsy patients using the MoCA-Ina questionnaire. The study involved 35 subjects. Results. Statistical analysis was conducted using the chi-square test and multivariate analysis with logistic regression. The chi-square test results revealed a significant relationship between age of onset and cognitive function (p=0,008), a significant relationship between seizure frequency and cognitive function (p=0,004), and a significant relationship between disease duration and cognitive function (p=0,012). The multivariate analysis results indicated that disease duration had a significant relationship with cognitive function, with an odds ratio of 0,081 (p-value=0,037, 95% CI 0,008-0,862). Conclusion. There is a relationship between age of onset, seizure frequency, and disease duration with the cognitive function of epilepsy patients at the Neurology Outpatient Clinic of Haji Adam Malik General Hospital in Medan.