Aktivitas Antibakteri Jahe Gajah (Zingiber Officinale Var Officinarum) terhadap Pertumbuhan Shigella Sonnei Penyebab Diare

Abstract

Introduction: Shigellosis is a bacterial infection that can cause diarrhea. Every year, approximately 165 million cases of Shigellosis infection are reported, with 1.1 million in developing countries. Diarrhea is the second-highest cause of death in children under 5 years old in 2019, totaling 370,000 cases. Shigella sonnei is a common Shigella infection in Indonesia. Due to increasing antibiotic resistance, there is a need to explore alternative treatments to replace antibiotic use for bacterial infections. Ginger has shown various antibacterial, antioxidant, antifungal, and other capabilities. Objective: To measure the antibacterial activity or capability of elephant ginger (Zingiber officinale Var Officinarum) in inhibiting the growth of Shigella sonnei. Method: The study conducted is experimental in nature. In this study, the Kirby-Bauer method was used, where the inhibition zones were measured on ginger extracts with concentrations of 10%, 20%, 40%, 60%, 80%, and 100% on the growth of Shigella sonnei on Mueller Hinton Agar. Results: In this research, ginger concentrations of 10%, 20%, 40%, 60%, and 80% did not show antibacterial capability, whereas ginger with a concentration of 100% showed inhibition zones measuring 8.3 mm, 8.1 mm, 7.65 mm, 9.45 mm, and 8.5 mm. Conclusion: Antibacterial activity can be observed in ginger extracts, but only at the highest concentration, which is 100%.