Korelasi Vitamin D dan Rasio Neutrofil Limfosit dengan Aktivitas Penyakit Arthritis Reumatoid di RSUP Haji Adam Malik

Abstract

IntroductionRheumatoid arthritis is a chronic inflammatory disease characterized by peripheral and symmetrical polyarthritis. Vitamin D deficiency has been linked to the course of several autoimmune diseases, and there is a link. In the process of autoimmune disease, the value of the neutrophil lymphocyte ratio is also known to be one of the parameters to assess the degree of activity. This study was conducted to assess the relationship between neutrophil lymphocyte ratio and rheumatoid arthritis disease activity. MethodThis research is a cross-sectional study with a retrospective approach, conducted from January to March 2023. This research was conducted on rheumatoid arthritis sufferers at Haji Adam Malik Hospital, Medan. Subsequent research subjects underwent anamnesis and physical examination to assess the DAS28 score. Blood sampling for examination of the ratio of neutrophil lymphocytes and vitamin D was carried out at Haji Adam Malik Hospital. The data collected was then analyzed using SPSS version 26. ResultsThere were 67 research subjects with an age range of 43-47 years. The research subjects consisted of 20 men and 47 women. MTX treatment history in the remission group was 56.7%, in the low disease activity group was 80% and in the moderate disease activity group was 81%. Leflunomide treatment history in remission group 43.3%, low disease activity group 20% and moderate disease activity group 19%. Correlation test of vitamin D levels and rheumatoid arthritis disease activity showed a p-value of 0.380. Correlation test of neutrophil lymphocyte ratio and rheumatoid arthritis disease activity showed a p-value of 0.862. Correlation test of vitamin D levels and neutrophil lymphocyte ratio with DAS28 using the speaman correlation showedp-valuesof 0.133. ConclusionThere was no significant relationship between vitamin D levels and neutrophil lymphocyte ratio with rheumatoid arthritis disease activity (p-value 0.133).