Hubungan Derajat iTILs (Intratumoral Infiltrating Lymphocytes) dan sTILs (Stromal Infiltrating Lymphocytes) dengan Ekspresi SOX2 (Sex-Determining Region Y (SRY)-BOX 2) pada Histopatologi Karsinoma Nasofaring

Abstract

Background: Nasopharyngeal carcinoma (NPC) is a type of malignant head and neck tumor originating from the epithelial lining of the nasopharynx which is commonly found in Asian countries, including Indonesia. SOX2 is part of SOX. The SOX gene family first emerged with the discovery of the mammalian testicular determinant, Sry. SOX2 expression in NPC is promoted by transcription factors such as activation protein 2 (AP-2), homeobox protein 1 (Prox1) and Pax6. TILs can be used systematically to evaluate a patient's anti-cancer immunological function, so they can be a valuable prognostic factor. Objective: To determine correlation between the degree of iTILs (intratumoral infiltrating lymphocytes) and sTILs (stromal infiltrating lymphocytes) with expression of immunohistochemical SOX2 (sex-determining region Y (SRY)-box 2) in the histopathology of nasopharyngeal carcinoma. Methods and Materials: 43 samples in the form of histopathological slides from biopsy/operative tissue diagnosed with nasopharyngeal carcinoma, reviewed slides and assessed for TILs both stromal and intratumoral by the researcher and two anatomic pathologists, then performed immunohistochemical staining of SOX2 and assessed for expression and then analyzed correlation between variables using the Spearman correlation test. Results: Based on the Spearman correlation test, there was no significant relationship between the degree of iTILs and SOX2 expression (p= 0.892) and there was a significant relationship between the degree of sTILs and SOX2 expression (p= 0.003). Conclusion: In this study, there was no significant relationship between the degree of iTILs and SOX2 expression, but there was a significant relationship between the degree of sTILs and SOX2 expression.