| dc.description.abstract | Introduction. Breast cancer is a condition that occurs when abnormal cells grow
uncontrollably, originating in the breast tissue. Breast cancer affecting women at
a very young age, ≤35 years old, is reported at a rate of 18.8 cases per 100,000
women, typically accompanied by a poor prognosis. Determining the diagnosis,
prognosis, and therapy for breast cancer can be achieved through
immunohistochemical (IHC) examinations to detect biomarkers such as estrogen
receptor (ER), progesterone receptor (PR), human epidermal growth factor
receptor-2 (HER2), as well as the Ki-67 proliferation index. Additionally,
clinicopathological examinations can be conducted to determine the
histopathological type, grading, and staging of breast cancer. Purpose. Analyzing
the relationship between immunohistochemistry and clinicopathology in very young
women breast cancer at H. Adam Malik General Hospital Medan from 2020 to
2023. Method. This study is analytical research with a retrospective cross-sectional
approach. The sample in this study consists of 38 medical record data samples that
meet the inclusion and exclusion criteria, which will be analyzed using the SPSS
application with the Fisher Exact method. Results. The research results indicate
that there is no significant relationship between immunohistochemistry and
histopathological type with a p-value of p=1.000 (>0.05). There is no significant
relationship between immunohistochemistry and grading with a p-value of p=0.974
(>0.05). There is no significant relationship between immunohistochemistry and
staging with a p-value of p=0.834 (>0.05). Conclusion. There is no significant
association was found between immunohistochemistry and clinicopathology of
breast cancer in very young women. | en_US |
