Perbandingan Efektivitas Pemberian Antibiotik Empiris Ceftriaxone dan Levofloxacin pada Pasien Sepsis dengan Community Acquired Pneumonia (CAP) di RSUP H. Adam Malik Medan Tahun 2020-2022

Abstract

Background: Approximately 40-50% of patients admitted to the ICU with sepsis present with a source of respiratory infection. CAP is the most common cause of sepsis in many reported cases. Appropriate empirical antibiotic therapy in sepsis is one of the most important factors for better outcome of sepsis patients with CAP. This study was conducted to compare the effectiveness of Levofloxacin and Ceftriaxone in empirical antibiotic therapy because these two drugs are the most commonly used drugs as empirical therapy according to the Germ Pattern and its sensitivity to antibiotics at H. Adam Malik Medan Hospital. Methods: the study was conducted retrospectively with secondary data sources obtained from medical records at H. Adam Malik Medan General Hospital for the period 2020-2022. The study population was all sepsis patients with CAP who underwent treatment at H. Adam Malik Hospital. Sample selection was based on inclusion and exclusion criteria. Results: There was no difference in the mortality value of research subjects using levofloxacin and ceftriaxone with a p value of 0.107. And there was no significant difference in the length of treatment between the groups administering levofloxacin and ceftriaxone antibiotics with a p value of 0.90. Conclusion: There is no significant difference between the effectiveness of the use of levofloxacin and ceftriaxone for sepsis patients with CAP at H. Adam Malik Hospital.