| dc.description.abstract | Background : Improved functional capacity is a good prognostic value in patients
after CABG. Phase II cardiac rehabilitation provides beneficial effects on physical
function, cardiopulmonary function, inflammatory response, autonomic function,
and improves functional capacity, and there is a significant decrease in
Interleukin-6 values in patients after CABG. Several studies have selected
Interleukin 6 as an inflammatory cytokine that can be used to assess the beneficial
effects of cardiac rehabilitation in coronary heart disease conditions. The aim of
the study was to determine the relationship of Interleukin-6 value as a predictor of
functional capacity improvement after phase II cardiac rehabilitation in patients
undergoing CABG.
Methods : This study was analytic observational study conducted retrospectively
on 31 CABG patients who underwent phase II cardiac rehabilitation. Data
collection on functional capacity, Interleukin-6 examination before and after
phase II cardiac rehabilitation. Data were analyzed univariately and bivariately to
assess the relationship between Interleukin-6 and functional capacity. Multivariate
analysis will then be performed using linear regression. The relationship test will
be performed with Pearson correlation test. Statistical data analysis using SPSS
software, p value <0.05 is statistically significant.
Results : There were 29 samples. The results of the cardiac exercise test showed
an increase in distance at the end of phase II cardiac rehabilitation compared to
the initial examination (457,655 ± 24,346 vs 180,482 ± 13,941). At the end of the
examination there was a decrease in the average Interleukin-6 level from 24.412 ±
2.516 to 13.647 ± 1.413. There was a significant relationship between
improvement in functional capacity and Interleukin-6 (p=0.032, r=0.40). An
increase of 1 MET will decrease Interleukin-6 by 2.238 pg/mL. There was a
decrease in mean Interleukin-6 from 24,412±2,516 to 13,647±1,413 at the end of
phase II with p value <0.001.
Conclusion : Interleukin-6 can be a predictor of improved cardiac functional
capacity after phase II cardiac rehabilitation program in patients undergoing
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