Hubungan Tingkat Penggunaan Antibiotika dengan Angka Resistansi Antimikroba di RSUP H Adam Malik Medan pada Tahun 2021 - 2022

Abstract

Background. Antimicrobial resistance is a global health issue, with many negative impacts that can reduce the quality of health care. Objective. This study aims to see the correlation between the level of antibiotic use and antimicrobial resistance rates at RSUP H. Adam Malik Medan in 2021 - 2022. Methods. This study is a retrospective design analytic study, by total sampling using secondary data from medical records of DDD antibiotics (ceftriaxone, cefotaxime, ceftazidime, and meropenem) and E. coli and K. pneumoniae to third generations of cephalosporin, CRE, CRAB, and CRPA resistance rates at RSUP H. Adam Malik Medan. Results. This study based on the linear regression test obtained a significant effect on the use of cefotaxime with E. coli resistance rate (p = 0.048) and K. pneumoniae (p = 0.048). The use of ceftriaxone with E. coli (p = 0.909) and K. pneumoniae (p = 0.361) resistance rates. The use of ceftazidime with E. coli (p = 0.650) and K. pneumoniae (p = 0.032) resistance rates. The use of meropenem with CR-E. coli (p = 0.047) and CR-K. pneumoniae (p = 0.739) resistance rates. Meropenem use with resistance rates of CRAB (p = 0.374) and CRPA (p = 0.227). Conclusions. From the results of this study, it can be concluded that there is a significant relationship between the use of cefotaxime with resistance rate of E. coli and K. pneumoniae, the use of ceftazidime with resistance rate of K. pneumoniae, and the use of meropenem with CR-E. coli resistance rate.