| dc.description.abstract | Background. Antimicrobial resistance is a global health issue, with many
negative impacts that can reduce the quality of health care. Objective. This study
aims to see the correlation between the level of antibiotic use and antimicrobial
resistance rates at RSUP H. Adam Malik Medan in 2021 - 2022. Methods. This
study is a retrospective design analytic study, by total sampling using secondary
data from medical records of DDD antibiotics (ceftriaxone, cefotaxime,
ceftazidime, and meropenem) and E. coli and K. pneumoniae to third generations
of cephalosporin, CRE, CRAB, and CRPA resistance rates at RSUP H. Adam
Malik Medan. Results. This study based on the linear regression test obtained a
significant effect on the use of cefotaxime with E. coli resistance rate (p = 0.048)
and K. pneumoniae (p = 0.048). The use of ceftriaxone with E. coli (p = 0.909)
and K. pneumoniae (p = 0.361) resistance rates. The use of ceftazidime with E.
coli (p = 0.650) and K. pneumoniae (p = 0.032) resistance rates. The use of
meropenem with CR-E. coli (p = 0.047) and CR-K. pneumoniae (p = 0.739)
resistance rates. Meropenem use with resistance rates of CRAB (p = 0.374) and
CRPA (p = 0.227). Conclusions. From the results of this study, it can be
concluded that there is a significant relationship between the use of cefotaxime
with resistance rate of E. coli and K. pneumoniae, the use of ceftazidime with
resistance rate of K. pneumoniae, and the use of meropenem with CR-E. coli
resistance rate. | en_US |
